Aging Research Center (ARC) E-mail: gregoria.kalpouzos@ki.se
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Grégoria Kalpouzos is Junior Research Professor at the Aging Research Center. She received her PhD in Psychology in 2007 at the University of Caen/Basse-Normandie (INSERM U923, France), and continued with her postdoctoral research from 2008 to 2010 at the Department of Integrative Medical Biology (Umeå University, Sweden). She is also a licensed psychologist, with training in the Departments of Neurology and Neurosurgery of the Hospital of Caen.
Grégoria’s primary area of research is the effects of aging on brain structure and function, in relation to cognitive processes, with a special focus on memory (episodic, prospective, emotional memory). She uses structural magnetic resonance imaging (T1-weighted and diffusion tensor imaging (DTI)), functional MRI and positron emission tomography (PET). She aims at combining multimodal neuroimaging data to improve our understanding of the normal and pathological aging effects, with an equal interest in deterioration, preservation and compensation.
Within the Swedish National study of Aging and Care in Kungsholmen (SNAC-K, a longitudinal population-based study), Grégoria is examining the impact of genetic polymorphisms, biological and environmental factors on health, longevity, and brain integrity.
Selected publications
Kalpouzos G, Persson J, Nyberg L. Local brain atrophy accounts for functional activity differences in normal aging. Neurobiology of Aging, in press.
Kalpouzos G, Nyberg L. Multimodal neuroimaging in normal aging: Structure-function interactions. In : Naveh-Benjamin, M., Ohta, N. (Eds), Current Perspectives on Memory and Aging. Psychology Press, in press.
Gonneau J*, Kalpouzos G*, Bon L, Viader F, Eustache F, Desgranges B. Distinct and shared cognitive functions mediate event- and time-based prospective memory impairment in normal aging. Memory, in press. *Equal contribution
Kalpouzos G, Eriksson J, Sjölie D, Molin J, Nyberg L (2010). Neurocognitive systems related to real-world prospective memory. PLoS ONE 5(10): e13304.
Nyberg L, Salami A, Andersson M, Eriksson J, Kalpouzos G, Kauppi K, Lind J, Pudas S, Persson J, Nilsson LG (2010). Longitudinal evidence for diminished frontal-cortex function in aging. Proceedings of the National Academy of Sciences 107(52): 22682-22686.
Persson J*, Kalpouzos G*, Nilsson LG, Ryberg M, Nyberg L. Preserved hippocampus activation in normal aging as revealed by fMRI. Hippocampus, in press. *Equal contribution
Kalpouzos G, Nyberg L (2010). Asymmetry of Memory in the Brain. In The two halves of the brain: Information processing in the cerebral hemispheres, K. Hugdahl & R. Westerhausen (Eds) MIT Press, Cambridge, MA, USA.
Kalpouzos G, Chételat G, Landeau B, Clochon P, Viader F, Eustache F, Desgranges B (2009). Structural and metabolic correlates of episodic memory performance in relation to the depth of encoding in normal aging. Journal of Cognitive Neuroscience 21(2): 372-389.
Kalpouzos G, Chételat G, Baron JC, Landeau B, Mevel K, Godeau C, Barré L, Constans JM, Viader F, Eustache F, Desgranges B (2009). Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging . Neurobiology of Aging 30(1): 112-124.
Chételat G, Fouquet M, Kalpouzos G, Denghien I, de la Sayette V, Viader V, Mézenge F, Landeau B, Baron J-C, Eustache F, Desgranges B (2008). Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry. Neuropsychologia 46 (6): 1721-1731.
Kalpouzos G, Eustache F, de la Sayette V, Viader F, Chételat G, Desgranges B (2005). Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients. Journal of Neurology 252:548-558.