Alina Solomon
Aging Research Center (ARC) E-mail: alina.solomon@ki.se alina.solomon@uku.fi Homepage: www.uku.fi/neuro/ |
Alina Solomon is a postdoctoral researcher at the Department of Neurology, University of Kuopio, Finland, and Aging Research Center, Karolinska Institutet. Her research interests include (a) the effects of vascular factors on late-life cognitive functioning, (b) the role of vascular and lifestyle-related factors in identifying people who are at increased long-term or short-term risk of developing dementia/cognitive impairment, (c) the links between cholesterol metabolism (particularly 24- and 27-hydroxycholesterol) and Alzheimer´s disease.
Alina is currently working with Professor Miia Kivipelto in a research network including Karolinska Institutet in Sweden, University of Kuopio and National Institute of Health and Welfare in Helsinki, Finland. The main epidemiological study Alina is involved in is CAIDE (Cardiovascular Risk Factors, Aging and Incidence of Dementia), but she also works with data from the Vantaa 85+ study, FINRISK study and with clinical data from the Memory unit at Karolinska University Hospital, Huddinge.
Alina is a medical doctor and received her PhD from the University of Kuopio in 2009. The title of her thesis is ´Cholesterol and late-life cognition. An epidemiological and clinical approach´ ( http://www.uku.fi/neuro/theses/index.shtml ).
Selected publications
Solomon A, Kivipelto M, Wolozin B, Zhou J, Whitmer RA. Midlife serum cholesterol and increased risk of Alzheimer’s and vascular dementia three decades later. Dement Geriatr Cogn Dis 2009;28(1):75-80.
Solomon A, Leoni V, Kivipelto M, Besga A, Oksengård AR, Julin P, Svensson L, Wahlund LO, Andreasen N, Winblad B, Soininen H, Björkhem I. Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. Neurosci Lett. 2009;462(1):89-93.
Solomon A, Kåreholt I, Ngandu T, Wolozin B, MacDonald SWS, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. Serum total cholesterol, statins and cognition in non-demented elderly. Neurobiol Aging, 2009;30(6):1006-9.
Solomon A, Kareholt I, Ngandu T, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study. Neurology. 2007;68(10):751-6.
Shafaati M, Solomon A, Kivipelto M, Björkhem I, Leoni V. Levels of Apo E in cerebrospinal fluid are correlated with Tau and 24S- hydroxycholesterol in patients with cognitive disorders. Neurosci Letters 2007;425(2):78-824.
Leoni V, Shafaati M, Solomon A, Kivipelto M, Bjorkhem I, Wahlund LO. Are the CSF levels of 24S-hydroxycholesterol a sensitive biomarker for mild cognitive impairment? Neurosci Letters 2006; 397; 83-87.
Kivipelto M, Solomon A. Preventive neurology: on the way from knowledge to action. Neurology. 2009;73(3):168-9.
Solomon A, Kivipelto M. Cholesterol-modifying strategies for Alzheimer's disease. Expert Rev Neurother. 2009;9(5):695-709.
Kivipelto M, Solomon A. Alzheimer's disease - the ways of prevention. J Nutr Health Aging 2008; 12(1):89S-94S.
Kivipelto M, Solomon A, Ngandu T. ´Vascular factors in Alzheimer’s disease: from diagnostic dichotomy to integrative etiology´. Chapter in the book ´Vascular Cognitive impairment in Clinical Practice´, editors Lars-Olof Wahlund, Timo Erkinjuntti, Serge Gauthier, Cambridge University Press 2009.